Defeat Doc Ock on Normal or higher difficulty

Defeat Doc Ock without taking damage on Normal or higher difficulty

Defeat the Lizard on Normal or higher difficulty

Defeat the Lizard twice without taking damage on Normal or higher difficulty

Defeat Electro on Normal or higher difficulty

Defeat Electro without taking damage on Normal or higher difficulty

Defeat The Sandman on Normal or higher difficulty

Defeat The Sandman without taking damage on Normal or higher difficulty

Defeat the Vulture on Normal or higher difficulty

Defeat the Vulture without taking damage on Normal or higher difficulty

Win the Pinball game on Normal or higher difficulty

Defeat Mysterio and collect his key on Normal or higher difficulty

Defeat Mysterio without taking damage on Normal or higher difficulty

Defeat The Hobgoblin on Normal or higher difficulty

Defeat The Hobgoblin without taking damage on Normal or higher difficulty

Defeat Venom on Normal or higher difficulty

Lure Venom to the Bell Tower and defeat him without taking damage on Normal or higher difficulty

Defuse the bomb on Normal or higher difficulty

Defuse the bomb with at least 20 hours remaining on Normal or higher difficulty

Defeat The Kingpin but fail to rescue Mary Jane on Normal or higher difficulty

Defeat The Kingpin and rescue Mary Jane on Normal or higher difficulty

Defeat The Kingpin without taking damage on Normal or higher difficulty

Defeat The Kingpin without stopping the chain or letting Mary Jane die on Normal or higher difficulty

Reach the exit on any level without touching the ground or any walls on Normal or higher difficulty

Collect all comics on Normal or higher difficulty

Collect all comics and complete all levels on Normal or higher difficulty

Complete the game and collect all comics in one session on Nightmare difficulty