Complete the Demons section in your Encylcopedia
Complete the Fiends section in your Encyclopedia
Recover all of your Appendages
Recover all of your Circulatory System
Recover all of your Digestive System
Recover all of your Endocrine System
Recover all of your Immune System
Recover all of your Muscular System
Recover all of your Nervous System
Recover all of your Oral Cavity
Recover all of your Respiratory System
Recover all of your Sensory System
Recover all of your Skeletal System
Recover all of your Chakra
Collect every Sword in the game
Collect enough of Jyukai's Medicine to gain a 1up
Defeat your first Fiend and regain your voice
Save Dororo in Yudai Village with 1 minute and 30 seconds or more remaining
Defeat the Hell Crusher and recover your Esophagus
Defeat Yudai
Defeat Yudai by only using your katana (no cannon, or Gatling gun; must enter fight with Katana)
Save Dororo from the cursed sword
Defeat the Giant Fire Wheel and recover your Kidneys
Defeat Tanosuke and recover your Spine
Defeat Twin Blade and regain your Ears
Defeat the Ogre and regain your Stomach
Defeat Gaping Maw without taking any damage and recover your Small Intestines
Defeat Mountainous and recover a Sense of Pain
Collect all Skill Scrolls
Defeat the Six-Tailed Fox and recover your Pancreas
Defeat the Nine-Tailed Fox
Defeat the Nine-Tailed Fox without using any ammo
Defeat the Thunder Fiend and recover your Lateral Muscles
Defeat Legion and recover your Nose
Save Hyakkimaru from the Gates of Hell with 1 minute and 30 seconds or more remaining
Defeat Midoro and restore your Right Eye
Kill over 250 demons
Defeat the Boar Fiend
Defeat Saburota
Defeat the Chimera Fiend
Defeat Fiend Tahoumaru
Recover all available body parts, then face off against Behemoth and win
[Dororo Mode] Clear Yakushi Riverside
[Dororo Mode] Clear Yudai's Manor - Basement
[Dororo Mode] Clear Nowaki Trail
[Dororo Mode] Clear Magistrate's Hidden Room
[Dororo Mode] Clear North Town - District 3
[Dororo Mode] Clear Shike Temple - Basement
[Dororo Mode] Clear Gates of Hell
[Dororo Mode] Clear Daigo's Castle - 3rd Floor