Kill Zerenski
Kill Slezz
Destroy the Shroud Tower
Kill Ephemera
Kill Unraveller
Kill Xerx
Acquire all guns
Acquire all powers
Acquire all special moves
Get 50 carnage kills in a single playthrough
Use all feeding fatalities in a single playthrough
Kill Kagan
Use all deathtrap types in a single playthrough
Bathe in the blood of 15 vampire lairs in a single playthrough