Clear the game once.
Clear the game on 'Painful' difficulty.
Clear the game on 'Nightmare' difficulty.
Clear the game on 'X Must Die' difficulty.
Beat the game as Jules.
Beat the game as Jeff.
Beat the game as Cordelia.
Beat the game as Digby.
Beat the game as Mumba.
Beat the game as Lydia.
Beat the game as Luis.
Beat the game as Fuji.
Unlock Cordelia.
Unlock Digby.
Unlock Mumba.
Unlock Lydia.
Unlock Luis.
Unlock Fuji.
Unlock every character in the game.
Unlock Jules's B costume.
Unlock Jeff's B costume.
Unlock Cordelia's B costume.
Unlock Digby's B costume.
Unlock Mumba's B costume.
Unlock Lydia's B costume.
Unlock Luis's B costume.
Unlock Fuji's B costume.
Unlock the B costume for every character.
Clear the Ground Floor.
Clear the Second Story.
Clear the Attic Sanctum.
Clear the Laboratory.
Clear Dark Mood Woods.
Clear the Foresaken Crypt.
Clear the Abandoned Set.
Clear the Sunken Ship.
Clear Exit Realm.
Get the true ending as Jules.
Get the true ending as Jeff.
Get the true ending as Cordelia.
Get the true ending as Digby.
Get the true ending as Mumba.
Get the true ending as Lydia.
Get the true ending as Luis.
Get the true ending as Fuji.
Assemble all four parts of the Silver Key.
Open the coffin.
Clear a challenge room in 15 seconds or less.
Knock out Chunks.
Visit 10 secret rooms in a single run.
Purchase Cordelia's entire stock on the first floor.
Complete a run in 20 minutes or less.
Carry over $1,000 at once.
Carry over $2,000 at once.
Carry over $3,000 at once.
Die.
Complete a run without taking a single hit.
Kill 6+ enemies with less than a second gap between each kill.
Leap off the balcony and loop your run.
Loop twice in a single run.
Get a Crusher in the Laboratory to land on Chunks.
Kill a Moth using a melee weapon as it's coming at you.
Press all 3 buttons in the Exit Realm within 5 minutes.
Collect 15+ items in a single run.
Collect 25+ items in a single run.
Collect 35+ items in a single run.
Complete a run without ever visiting a shopkeeper.
Max out all your stats with Dr. Cordelia.
Destroy 5+ weapons in a single run.
As Digby, get a 20+ kill combo.
Destroy a full ammo Golden Gun as Luis.
Get 10+ reward items in a single run as Lydia.
Purchase a shop's entire stock as Cordelia.
As Fuji, kill a boss in under 30 seconds.
Obtain a Mumba Launcher as Mumba.
Clear a run without picking up, firing, or scrapping a single weapon besides your Shotgun or Rocket Launcher as Jules.
As Jeff, clear a run without any items.
Break 10 golden pots in a single run.
...if you want to live.
RUNRUNRUNRUNRUNRUNRUNRUNRUN
Reach Diavola.
Kill Diavola.
Unlock EVERY medal.
Clear the Arena.
Find the wanted poster.
As BOSS, kill a boss in under ten seconds.
Beat the game as BOSS.
Get the true ending as BOSS.
As BOSS, obtain 10+ explosive-related items.
Purchase an item using Toilet Paper in the Bathroom.
Buy the toilet's entire stock in the Bathroom.
Store $200 in the bank.
Store $1,000 in the bank.
Store $2,000 in the bank.
Store $5,000 in the bank.
Store $10,000 in the bank.
Store $20,000 in the bank.
Complete a run with every individual Curse enabled as Jules.
Complete a run with every individual Curse enabled as Jeff.
Complete a run with every individual Curse enabled as Cordelia.
Complete a run with every individual Curse enabled as Digby.
Complete a run with every individual Curse enabled as Mumba.
Complete a run with every individual Curse enabled as Lydia.
Complete a run with every individual Curse enabled as Luis.
Complete a run with every individual Curse enabled as Fuji.
Complete a run with every individual Curse enabled as BOSS.
Unlock the C costume for every character.
Hold 10 Chunks Medallions at once.
Hold 50 Chunks Medallions at once.
Purchase your first Curse from Filia.
Purchase a blessing from Faith.
Find a place to rest.
Find Axel's secret hideaway.
As Axel, find and pick up a Laser Blade.
Complete a run with every individual Curse enabled as Axel.
Beat the game as Axel.
Get the true ending as Axel.
As Axel, deal 100+ damage in a single hit with your Hatchets.
Complete Assignment Anya.
Complete Massive Attack.
Complete the Gauntlet.
Complete Jumbled Mess.
Complete Blackout.
Complete Old Grounds.
Complete Hemophiliac.
Complete Mutants.
Complete No Spill Blood.
Complete Mom's Credit Card.
Complete the Great Depression.
Complete Arcade Maniac.
Achieve an S rank in Assignment Anya.
Achieve an A rank in Assignment Anya.
Achieve a B rank in Assignment Anya.
Achieve a C rank in Assignment Anya.
Complete Assignment Anya in under one hour.
Complete Assignment Anya by using one or fewer healing items.
Complete Assignment Anya by saving your progress a single time or less.
Melt the ice cube manually.
Let the ice cube melt on its own.
Escape the mansion with the duck floaty.
Warp across the mansion using a mirror.
Complete every challenge.