Defeat Brock and earn the Boulder Badge
Defeat Misty and earn the Cascade Badge
Defeat Lt. Surge and earn the Thunderbadge
Defeat Erika and earn the Rainbow Badge
Defeat Daisy and earn the Earth Badge
Defeat Koga and earn the Marsh Badge
Defeat Sabrina and earn the Soul Badge
Defeat Blaine and earn the Volcano Badge
Defeat Brock, Set Mode, Levels <=16
Defeat Misty, Set Mode, Levels <=27
Defeat Lt. Surge, Set Mode, Levels <=32
Defeat Erika, Set Mode, Levels <=42
Defeat Daisy, Set Mode, Levels <=47
Defeat Koga, Set Mode, Levels <=52
Defeat Sabrina, Set Mode, Levels <=59
Defeat Blaine, Set Mode, Levels <=63
Defeat the Champion
Defeat the Elite 4 and Champion, Set Mode, Levels <=76 (One Session)
Defeat both Rivals on your way to Route 1
Defeat Kamon in Viridian City
Defeat the optional Rival fight near Viridian City
Defeat the optional rival fight in Viridian Forest
Defeat Kamon inside the Pewter City Museum
Buy the Magikarp in the Pokemon Center just outside Mt. Moon
Defeat Executive Ariana in Mt. Moon
Defeat Daisy at the end of Route 25
Defeat Kamon on the SS Anne
Obtain the Eevee Egg
Defeat Giovanni in the Team Rocket Hideout
Defeat Kamon at the top of Pokemon Tower
Obtain the Bike from the Bike Shop
Catch 5 different Pokemon in one Safari Zone run
Defeat Karate King Kiyo in Saffron to obtain a special Pokemon
Defeat Giovanni at Silph Co.
Defeat Executive Archer in the Pokemon Mansion
Make your way through Cerulean Cave, and Capture Mewtwo
Defeat Giovanni in Cerulean Cave
Catch Heatran atop Mt. Blaze
Defeat all of the Gym Leader rematches in S Area, without leaving in one session
Defeat Brock in a Rematch
Defeat Misty in a Rematch
Defeat Lt. Surge in a Rematch
Defeat Erika in a Rematch
Defeat Daisy in a Rematch
Defeat Koga in a Rematch
Defeat Sabrina in a Rematch
Defeat Blaine in a Rematch
Defeat Your Rival in a Rematch
Catch Mew on Faraway Island
Catch Deoxys on Birth Island
Capture Articuno at Seafoam Islands
Capture Zapdos at the Power Plant
Capture Moltres at Victory Road
Catch all 210 available Pokemon