Rescue 50 Citizens.
Get three medals in any mission on one difficulty.
Complete the first act.
Complete the second act.
Complete the game as the hero of the citizens.
Complete the third act.
Get all medals for all missions of the Acts on Normal difficulty.
Get all medals for all missions of the Acts on Hardcore difficulty.
Get all medals for all missions of the Acts on Nightmare difficulty.
Get all medals for all missions of the Acts on Grim difficulty.
Purchase all cyberware.
Purchase all weapon mods.
Upgrade four special weapons to the max.
Upgrade four Gavel firemodes to the max.
Find all collectibles.