Choose the path of a hero and defeat some thieves. [Hero 1-1]

Defeat some goons. [Hero 1-2]

Defeat some punks (both groups). [Hero 1-3]

Defeat Lizard and Rhino. [Hero 1-4]

Defeat Vulture and Electro. [Hero 1-5]

Defeat Doctor Octopus. [Hero 1-6]

Defeat the Green Goblin, twice. [Hero 1-7]

Defeat the robot enforcer and the robot sentry. [Hero 2-1]

Defeat Lady Deathstrike. [Hero 2-2]

Defeat Black Tom Cassidy and the Juggernaut. [Hero 2-3]

Defeat Mystique. [Hero 2-4]

Defeat the Blob, Avalanche, Pyro, and Toad. [Hero 2-5]

Defeat Sabretooth. [Hero 2-6]

Defeat Magneto, twice. [Hero 2-7]

Defeat Moleman (with both heroes). [Hero 3-1]

Defeat Annihilus. [Hero 3-2]

Defeat the Skrull soldiers. [Hero 3-3]

Defeat Super Skrull and some more soldiers. [Hero 3-4]

Defeat the guards and the robots. [Hero 3-5]

Defeat all of the Doom-Bots. [Hero 3-6]

Defeat Doctor Doom, 3 times. [Hero 3-7]

Defeat Hammerhead. [Hero 4-1]

Defeat Kingpin. [Hero 4-2]

Defeat Morbius. [Hero 4-3]

Defeat Mysterio and Speed Demon (within 6 turns). [Hero 4-4]

Defeat Carnage. [Hero 4-5]

Defeat Kaine and the Jackal (in all 4 battles). [Hero 4-6]

Defeat Venom (while keeping his allies to a minimum). [Hero 4-7]

Defeat Cobra and Mr. Hyde. [Hero 5-1]

Defeat Deadpool and the Russian. [Hero 5-2]

Defeat the mercenaries. [Hero 5-3]

Defeat Steel Wind and Tryks. [Hero 5-4]

Defeat Anton Hellgate and some vampires. [Hero 5-5]

Defeat Dracula and Werewolf by Night. [Hero 5-6]

Defeat Nightmare. [Hero 5-7]

Defeat the Hand. [Hero 5-8]

Defeat Bullseye (after KO'ing Sniper). [Hero 5-9]

Defeat Kang and his guards. [Hero 6-1]

Defeat Growing Man and his guards. [Hero 6-2]

Defeat Citizen V and Vantage. [Hero 6-3]

Defeat another Kang and his guards. [Hero 6-4]

Defeat Baltag and a third Kang. [Hero 6-5]

Defeat Enchantress, twice. [Hero 6-6]

Defeat Tempus and Ultron. [Hero 6-7]

Defeat Melter and the Executioner. [Hero 6-8]

Defeat yet another Kang and his guards. [Hero 6-9]

Defeat Amenhotep and a fifth Kang. [Hero 6-10]

Defeat two more Kangs. [Hero 6-11]

Defeat Ultron 5. [Hero 6-12]

Defeat the final Kang. [Hero 6-13]

Defeat Mark II, Number II. [Hero 7-1]

Defeat Tri-Sentinel. [Hero 7-2]

Defeat Nimrod (both times). [Hero 7-3]

Defeat (and KO) Mr. Sinister. [Hero 7-4]

Defeat (and KO) Master Mold to complete the Hero campaign. [Hero 7-5]

Choose the path of a villain and defeat the traitors. [Villain 1-1]

Defeat some cops. [Villain 1-2]

Defeat Cloak and Dagger. [Villain 1-3]

Defeat Tombstone and his underlings. [Villain 1-4]

Defeat the Jackal and his henchmen. [Villain 1-5]

Defeat Doctor Octopus. [Villain 1-6]

Defeat Spider-Man, twice. [Villain 1-7]

Defeat a robot enforcer and some guards. [Villain 2-1]

Defeat Luke Cage and She-Hulk. [Villain 2-2]

Defeat Dragon-Man. [Villain 2-3]

Defeat Gambit. [Villain 2-4]

Defeat Cyclops, Colossus, Iceman, and Shadowcat. [Villain 2-5]

Defeat Wolverine. [Villain 2-6]

Defeat Professor X, twice. [Villain 2-7]

Defeat the Doom-Bots. [Villain 3-1]

Defeat Zorba and his followers. [Villain 3-2]

Defeat Darkoth. [Villain 3-3]

Defeat the Atlantian soldiers and macrobots. [Villain 3-4]

Defeat the Sub-Mariner. [Villain 3-5]

Defeat Mr. Fantastic and the Invisible Woman. [Villain 3-6]

Defeat the Thing, twice. [Villain 3-7]

Defeat Daredevil. [Villain 4-1]

Defeat the Scarlet Spider. [Villain 4-2]

Defeat the Punisher. [Villain 4-3]

Defeat Silver Sable and the Wild Pack. [Villain 4-4]

Defeat Spider-Woman. [Villain 4-5]

Defeat Black Cat, Firestar, Hornet, and Ricochet (within 6 turns). [Villain 4-6]

Defeat Spider-Man (while keeping his allies to a minimum). [Villain 4-7]

Defeat Black Widow. [Villain 5-1]

Defeat Luke Cage and the Iron Fist. [Villain 5-2]

Defeat Venus Dee Milo and Doop. [Villain 5-3]

Defeat the Ghost Rider. [Villain 5-4]

Defeat Blade and Brother Voodoo. [Villain 5-5]

Defeat Doctor Strange and Hannibal King. [Villain 5-6]

Defeat Shang Chi. [Villain 5-7]

Defeat Moon Knight and the Punisher. [Villain 5-8]

Defeat (and KO) Elektra. [Villain 5-9]

Defeat Vision and the Scarlet Witch. [Villain 6-1]

Defeat Captain Marvel and Beast. [Villain 6-2]

Defeat the Black Panther and She-Hulk. [Villain 6-3]

Defeat Giant Man and Wonder Man. [Villain 6-4]

Defeat Thor and Warbird. [Villain 6-5]

Defeat Captain America, twice. [Villain 6-6]

Defeat Piledriver and Thunderball. [Villain 6-7]

Defeat Hawkeye and the Golden Archer. [Villain 6-8]

Defeat Doctor Spectrum and Power Princess. [Villain 6-9]

Defeat Hyperion. [Villain 6-10]

Defeat Thor (with both characters). [Villain 6-11]

Defeat Hulk. [Villain 6-12]

Defeat Kang. [Villain 6-13]

Unlock all 18 Playmats.

Defeat Mark II, Number II. [Villain 7-1]

Defeat Tri-Sentinel. [Villain 7-2]

Defeat Bastion (both times). [Villain 7-3]

Defeat (and KO) Mr. Sinister. [Villain 7-4]

Defeat Nimrod and Master Mold (after KO'ing) to complete the Villain campaign.

Complete all 6 Loyalty Puzzles.

Complete all 6 Boost Puzzles.

Complete all 6 Evasion Puzzles.

Complete Reservist puzzles 1-4.

Complete all 5 Concealed Puzzles.

Complete all 5 Leader Puzzles.

Complete every puzzle in the game (excluding Reservist 5).