Collect the "Accumulator" collection

Collect the "Anti-Clotting Lubricant" collection

Collect the "Card Shark Deck" collection

Collect the "Crimson Moonstone" collection

Collect the "Deedstalker" collection

Collect the "Elephant Figurine" collection

Collect the "Bonsai Tree" collection

Collect the "Eye of Providence Amulet" collection

Collect the "Ice Crown" collection

Collect the "Merchant Guild Medalion" collection

Collect the "Mystical Sphere" collection

Collect the "Neurotoxins Grimoire" collection

Collect the "On the Origin of Species" collection

Collect the "Pharaoh's Mask" collection

Collect the "Pith Helmet" collection

Collect the "Straitjacket" collection

Collect the "Tourist Backpack" collection

Collect the "Turban" collection

Collect the "Vampire Jaw" collection

Defeat the Shub-Niggurath boss fight

Defeat the Ithaqua boss fight

Defeat the Dagon boss fight

Defeat the Cthulhu boss fight

Complete the story stage "Awakening the Monolith"

Complete the story stage "Finding Allies"

Complete the story stage "Tension rises"

Complete the story stage "The Betrayal"

Complete the story stage "The Last Hope"

Complete the story stage "The Final"

Complete the campaign mode story

Game Over for losing all HP

Game Over for losing all Sanity

Game Over for not having fuel

Level up The Monolith to level 5

Level up The Monolith to level 10

Level up The Monolith to level 15

Level up The Monolith to level 20

Level up The Monolith to level 25

Level up The Monolith to level 50

Unlock the Professor in campaign mode

Unlock the Cultist in campaign mode

Unlock all starting decks in campaign mode

Constuct all the buildings in campaign mode

Upgrade any building to maximum level in campagn mode (except for Propaganda Center)

Upgrade all buildings to maximum level in campagn mode

Fuse a Super-Sphere in campaign mode

Finish investigating Head's case

Finish investigating Hand's case

Finish investigating Brain's case

Finish investigating Julia's case

Finish investigating Grim's case

Finish investigating Weirdo's case

Complete all investigations in campaign mode

Complete 3 acts in campaign mode as a Detective

Complete 3 acts in campaign mode as a Professor

Complete 3 acts in campaign mode as a Cultist

Make 3 purchases from the Merchant at the same time

Try all options for any Encounter

Complete the campaign mode at 100%

Defeat the Hastur boss fight

Complete 3 acts as the Detective in "Custom Game" mode on at least medium difficulty with a normal number of enemies.

Complete 3 acts as the Professor in "Custom Game" mode on at least medium difficulty with a normal number of enemies.

Complete 3 acts as the Cultist in "Custom Game" mode on at least medium difficulty with a normal number of enemies.

Defeat Cthulhu in "Custom Game" mode.

Complete 3 acts with a Mixed Deck in "Custom Game" mode.

Complete 3 acts on high difficulty with an increased number of enemies in "Custom Game" mode.

Collect the "Gas Mask" collection

Collect the "Menorah" collection

Collect the "Phrenology Bust" collection

Collect the "Stamped Passport" collection