Complete chapter 1

Complete chapter 2

Complete chapter 3

Complete chapter 4

Complete chapter 5

Complete the game in hard puzzle difficulty

Complete the game in hard shooter difficulty

Complete the game with both difficulties set to hard

Complete the game with no life upgrade

Complete the game with no upgrade for cube speed

Complete the game with no shield size reduction

Buy at least one point in every skill

Reach the maximum levels for all skills

Earn all gold medals in story mode

Earn all diamond medals in story mode

Earn all chain reaction gold medals in story mode

Earn all chain reaction diamond medals in story mode

Earn all time gold medals in story mode

Earn all time diamond medals in story mode

Earn all life gold medals in story mode

Earn all life diamond medals in story mode

Reach a gold rating in the 5 challenges

Reach a diamond rating in the 5 challenges

Earn all diamond medals for the DNA chain defense

Be awarded with 20 macroshots in a single level

Complete sample 14 without slowing the chain

Complete sample 17 without being poisoned once by toxins

Complete sample 8 without destroying a single bloated cell

Complete sample 25 without using the EMP

Complete sample 12 without touching a single sticky web

Complete sample 21 without colliding with a single flagellate pathogen

Be awarded with an extra chain reaction in chapter 4 or 5

Destroy one virus pathogen in sample 11, 12 or 13

Reach the last wave difficulty in the 5 challenges

Destroy 6 critical cubes in any sample of the story mode