Mutate for the first time.

Kill 666 enemies across all runs.

Mutate 66 times across all runs.

Mutate 6 times in a single run.

Kill your first enemy.

Kill 66 enemies in a single run.

Clear a floor of all enemies.

Deal 66 or more damage in a single attack.

Deal 6666 damage across all runs.

Go to 1 health.

Go insane once.

Die from insanity.

Use an item.

Use 33 items in a single run.

Use each item at least once across all runs.

Use 666 items across all runs.

Damage an enemy with a Combustion Icon.

Poison an enemy with a Poison Icon.

Kill an enemy with a Death Icon.

Freeze an enemy with an Ice Icon.

Enter the House of Silence.

Enter the cavern.

Enter the swamp.

Enter the underground lake.

Enter the ice caves.

Enter the eldritch floor.

Enter the final floor.

Complete the first loop.

Complete the second loop.

Complete the third loop.

Complete the fourth loop.

Complete the fifth loop.

Complete the sixth loop.

Complete the final loop.

Complete a run without mutating.

Complete a run without attacking.

Die for the first time.

Turn yourself into just an Evil Eye.

Die on the final floor.

Mutate your head with Rogue RNA.

Kill yourself by hitting a prickly enemy.

Pull a Painful Portal out of a Painful Portal.

Use the Skull of Ibid.

Die 66 times.

Choose each mutation at least once across all runs.

Take 6666 damage across all runs.

Damage 3 enemies with a Mindwave Stone.

Mutate 3 enemies with an Evolution Stone.

Freeze 3 enemies with an Ice Stone.

Damage 3 enemies with a Combustion Stone.

Poison 3 enemies with a Poison Stone.

Set speed to 100 or greater.

Walk 66666 steps.

Hold 666 bones at one time.

Gain 66666 bones across all runs.

Carry 10 items at one time.

Achieve all other achievements.