Beat each base game boss with a perfect clear, also not using missiles or consumables.

Beat the boss "Crystal Mother" with a perfect clear, also not using missiles or consumables.

Beat the boss "Battleswarm" with a perfect clear, also not using missiles or consumables.

Beat the boss "WallMaster" with a perfect clear, also not using missiles or consumables.

Beat the boss "Mirror" with a perfect clear, also not using missiles or consumables.

Beat the boss "Backfire" with a perfect clear, also not using missiles or consumables.

Beat the boss "ShrapnelRose" with a perfect clear, also not using missiles or consumables.

Beat the boss "LadyStaccato" with a perfect clear, also not using missiles or consumables.

Beat the boss " Labyrinth" with a perfect clear, also not using missiles or consumables.

Beat the boss "Aggressor" with a perfect clear, also not using missiles or consumables.

Beat the boss "Centrifuge" with a perfect clear, also not using missiles or consumables.

Beat the boss "Vestige" with a perfect clear, also not using missiles or consumables.

Beat the boss "Fusillade" with a perfect clear, also not using missiles or consumables.

Beat the boss "Aberration" with a perfect clear, also not using missiles or consumables.

Beat the boss "The Warden" with a perfect clear, also not using missiles or consumables.

Beat the boss "Terminus" with a perfect clear, also not using missiles or consumables.

Beat each miniboss with a perfect clear, also not using missiles or consumables.

Beat each condemned boss.

Complete a floor with no damage.

Complete a run without buying any items.

Complete a run without picking up any attachment items.

Satisfy the unlock conditions for all items.

Actually find (pick up) every single item.

Kill at least one of each non-boss enemy.

Kill a shopkeeper.

Have 5 familiars at once.

Pick up the Incredibility Life Harvester on the first floor, never drop it, and win the run.

Pick up the Incredibility Minimalist on the first floor, never drop it, and win the run.

Pick up the Incredibility Consummate Consumer on the first floor, never drop it, and win the run.

Pick up the Incredibility The One on the first floor, never drop it, and win the run.

Pick up the Incredibility Magnetic Personality on the first floor, never drop it, and win the run.

Pick up the Incredibility Jaywalker on the first floor, never drop it, and win the run.

Pick up the Incredibility Confidence on the first floor, never drop it, and win the run.

Pick up the Incredibility Risky Assassin on the first floor, never drop it, and win the run.

Kill the "final" boss while using the Deep Blue mech.

Kill the "final" boss while using the Green Envy mech.

Kill the "final" boss while using the Flame Tank mech.

Kill the "final" boss while using the Indigo Dipole mech.

Kill the "final" boss while using the Redshift mech.

Kill the "final" boss while using the White Gloss mech.

Kill the "final" boss with each of the original six mechs.

Kill the "real" final boss with the Deep Blue mech.

Kill the "real" final boss with the Green Envy mech.

Kill the "real" final boss with the Flame Tank mech.

Kill the "real" final boss with the Indigo Dipole mech.

Kill the "real" final boss with the Redshift mech.

Kill the "real" final boss with the White Gloss mech.

Kill the "real" final boss with each of the original six mechs.

Beat the boss "Invader" with a perfect clear, also not using missiles or consumables.

Kill the "final" boss while using the Humble mech.

Kill the "final" boss while using the Alpha mech.

Kill the "final" boss while using the Penumbra mech.

Kill the "real" final boss with the Humble mech.

Kill the "real" final boss with the Alpha mech.

Kill the "real" final boss with the Penumbra mech.

Beat the boss "Meridian" with a perfect clear, also not using missiles or consumables.

Beat the boss "Rive" with a perfect clear, also not using missiles or consumables.

Beat the boss "Circuit Rondure" with a perfect clear, also not using missiles or consumables.

Beat the boss "Pandemonium" with a perfect clear, also not using missiles or consumables.

Beat the boss "Reanimator" with a perfect clear, also not using missiles or consumables.

Beat the boss "Recast" with a perfect clear, also not using missiles or consumables.

Beat the boss "Nova" with a perfect clear, also not using missiles or consumables.

Beat the boss "CarrionEngine" with a perfect clear, also not using missiles or consumables.

Beat the boss "Javelin" with a perfect clear, also not using missiles or consumables.

Beat each AuGMENTED boss with a perfect clear, also not using missiles or consumables.

Kill the "final" boss while using the Zephyr mech.

Kill the "final" boss while using the Warhog mech.

Kill the "final" boss while using the Paladin mech.

Kill the "real" final boss with the Zephyr mech.

Kill the "real" final boss with the Warhog mech.

Kill the "real" final boss with the Paladin mech.

Pick up the Incredibility The Creator on the first floor, never drop it, and win the run.

Pick up the Incredibility Lilliputians on the first floor, never drop it, and win the run.

Pick up the Incredibility High Speed Danger on the first floor, never drop it, and win the run.

Pick up the Incredibility Corrupting Power on the first floor, never drop it, and win the run.

Beat the boss "Periphery" with a perfect clear, also not using missiles or consumables.

Beat the boss "Metal Legion" with a perfect clear, also not using missiles or consumables.

Beat the boss "Sunder" with a perfect clear, also not using missiles or consumables.

Beat the boss "The Humbled" with a perfect clear, also not using missiles or consumables.

Beat the boss "Valor" with a perfect clear, also not using missiles or consumables.