Finish First Challenge by winning 4 battles.
Supply power to the Golden Gate Bridge.
Finish speaking with Nana to complete the challenge End of Humanity.
Defeat the mysterious lady Mii.
Defeat Class-A alien Mii.
Destroy 7 Eaters.
Destroy 20 Hornets.
Destroy 8 Jumbo Heads.
Destroy 10 Wheels.
Destroy 2 Chickens.
Destroy 20 Cubes.
Destroy 10 Boots Cats.
Destroy 10 Warriors.
Destroy 10 Hands.
Destroy 30 Biters.
Destroy 5 Heavy Gears.
Destroy 10 Green Peas.
Destroy 5 John Doe.
Destroy 12 Vesps.
Destroy 15 Vampires.
Destroy 10 Shot Man.
Destroy 15 Cone Heads.
Destroy 15 Bull Biters.
Destroy 15 Crawlers.
Destroy 5 Gunners.
Destroy 20 Mini Raibbts.
Destroy 15 Hell Stamps.
Destroy 4 Golden Dawns in San Francisco Free Hunt.
Destroy 8 Golden Dawns in San Francisco Free Hunt.
Destroy 12 Golden Dawns in San Francisco Free Hunt.
Destroy 4 Golden Dawns in New York City Free Hunt.
Destroy 8 Golden Dawns in New York City Free Hunt.
Destroy 12 Golden Dawns in New York City Free Hunt.
Destroy 4 Golden Dawns in Moscow Free Hunt.
Destroy 8 Golden Dawns in Moscow Free Hunt.
Destroy 9 Golden Dawns in Moscow Free Hunt.
Destroy 4 Golden Dawns in Fuji Jukai Free Hunt.
Destroy 8 Golden Dawns in Fuji Jukai Free Hunt.
Destroy 12 Golden Dawns in Fuji Jukai Free Hunt.
Destroy 3 Golden Dawns in Tokyo Free Hunt.
Destroy 6 Golden Dawns in Tokyo Free Hunt.
Destroy 9 Golden Dawns in Tokyo Free Hunt.
Destroy 3 Golden Dawns in Moon Free Hunt.
Destroy 6 Golden Dawns in Moon Free Hunt.
Destroy 9 Golden Dawns in Moon Free Hunt.
Defeat Mii again during the Free Hunt Mission.
Deliver Xiaoming's letter to Phobos with no damage.
Thoroughly flatter Nafe by destroying every Pink Eater before the last White Eater.
Destroy 5 Death Jackets with Tracer Gun.
Destroy 5 Zaha Symbols with War Hammer.
Use the Charge Shot to destroy 5 Smokers.
Destroy Lucky Dice.
Destroy White Wall.
Destroy 5 Spiders using Vulcannon.
Destroy Wild Turkey.
Destroy a Pain Carrier using Star Comet.
Finish Tokyo Missions up to Dancing Pink Rabbit to finish To Nana.
Destroy 5 Pink Cradles with Blade Kill.
Destroy 5 Zaha Dice with Volcane.
Destroy 5 Kabuto Mashers with Iksa Blade.
Destroy 5 Kabuto Gunners with Burst Shot.
Defeat A Class aliens Shizu and Karli.
Finish Operation Piggy Ninja.
Finish the 3 bike missions without taking damage.
Find and defeat Mazuma.
Defeat MZMA again during the Free Hunt Mission.
Defeat A Class alien Mazuma.
Complete 2 EX Driving Missions with no damage.
Allow time to run out twice without destroying anything, then defeat all 6 Bigmouths.
Defeat the A Class alien Nafe.
Defeat the A Class alien Zaha.
Look for the world's last woman.
Follow Nana wherever she goes.
Find and defeat Shizu and Karli.
Beat Shizu and Karli again during the Free Hunt Mission.
Cause a max damage of 99,999 during Nana's test to unlock School Girl costume.
Defeat A Class alien Lilio.
Meet Nana in 5 minutes.
Find and defeat Lilio.
Defeat Lilio again during the Free Hunt Mission
Clear Survival Limit with at least 50 percent HP left.
Defeat Nafe again in the Free Hunt Mission.
Defeat A Class alien Zaha.
Destroy WRS to finish the game on Normal Mode.
Defeat Zaha in the Free Hunt Mission.
Complete all Hunt Missions.
Destroy all 78 Golden Dawns to unlock Moon Rabbit costume.
Finish all PSS ? missions in Extra Mode.
Complete the game after finishing all ? missions to get the best ending.
Finish all Nana missions.
Beat every Class-A alien again in Extra Missions.
Defeat all 7 Aliens during the final mission The Last Game.
Defeat WRS during The Last Game.
Reach Level 50 for BRS to unlock Poolside costume.
Finish every challenge in the game to unlock a Special Gallery image.
Find the passive ability Aftercare.
Find the passive ability Aftercare Plus.
Find the passive ability Max Up.
Find the passive ability Rocket Starter.
Find the passive ability Six Pocket.
Find the passive ability Attack Free.
Find the passive ability Danger Guard.
Find the passive ability Sway Three.
Find the passive ability Treasure Hunt.