Complete 3 areas with Darkness Level 5 or less in a single run.

Complete 3 areas with Darkness Level 15 or more in a single run.

Defeat Tortured Corpse and Maniac before they heal.

Have 12 different conditions on a single entity.

In Story Mode, reach the end of Streets or Factory under 15 minutes (turn-based time).

In Story Mode, reach the end of Hospital or Lair under 15 minutes (turn-based time).

Defeat the Scientist or the Subject before they use Wall move second time.

Defeat the Baron before his friends.

Defeat the Corpulent Worm and Carcasses in the same turn.

Defeat the Horned Rat & Albino Rat under 2 seconds.

Defeat the Carcasses by slaying the Carcass of Control last.

Defeat 3 enemies in a single encounter without dealing direct damage.

Defeat the Crawler Brute by getting Webbed, but not using any Struggle cards.

Stagger the Claw.

Defeat the Old Patient by slaying it when the Sentries are dead.

Reach the end of Hospital or Lair without recruiting companions during the whole run.

Reach the end of Streets or Factory without recruiting companions during the whole run.

Reach the end of Hospital or Lair without using Pills or Vitamins the whole run.

Unlock Cara.

Reach the end of Hospital or Lair by starting with a syringe-only deck. (In Story Mode)

Reach the end of Hospital or Lair by starting with an axe-only deck. (In Story Mode)

Reach the end of Hospital or Lair by starting with a flashlight-only deck. (In Story Mode)

Trigger more than 100 Bleeding damage at once.

Deal more than 100 Physical damage at once.

Kill an enemy.

Defeat the Baron.

Defeat the Baron with Cara.

Deal more than 100 Light damage at once.

Help the little robot get a new body.

Reach the end of Hospital.

Reach the end of Part 1.

Print an item using a blueprint you've recorded.

Defeat the Scientist or the Subject with all equipment on your hero removed (including weapons).

Defeat the Daemon.

Dismember an enemy.

Deal more than 100 Acid damage at once.

Deal more than 100 Dark damage at once.

Reach the end of Hospital or Lair by starting with a spray gun-only deck. (In Story Mode)

Reach the end of Hospital or Lair by starting with a shield-only deck.

Obtain Daemon Head.

Reach the end of Hospital or Lair without buying anything from Shops or Old Hag. (In Story Mode)

Defeat the Factory Chief.

Defeat the Organization Boss.

Reach the end of Part 2.

Reach Ending 1.

Reach Ending 2.

Reach Ending 3.

Defeat Bubblegum.

Defeat the Daemon II under 15 seconds.

Defeat Brain Artifact by using Negate Barrier move only once.

Defeat the Dolls while a companion isn't Captured.

Defeat Frail by slaying it while both Incubators are alive.

Defeat Queen Wasp with hero losing no health.

Defeat Infernal Beast under 10 seconds.

Defeat Earth Eroding Worm under 10 seconds.

Defeat Disease and Great Shield by slaying the Disease first.