Survive the incident
Find the heart of the Sol Sanctum
Find Flint, the first Venus Djinni
Find Granite, the second Venus Djinni
Find Quartz, the third Venus Djinni
Find Vine, the fourth Venus Djinni
Find Sap, the fifth Venus Djinni
Find Ground, the sixth Venus Djinni
Find Bane, the seventh Venus Djinni
Recruit Ivan
Find Forge, the first Mars Djinni
Find Fever, the second Mars Djinni
Find Corona, the third Mars Djinni
Find Scorch, the fourth Mars Djinni
Find Ember, the fifth Mars Djinni
Find Flash, the sixth Mars Djinni
Find Torch, the seventh Mars Djinni
Find Gust, the first Jupiter Djinni
Find Breeze, the second Jupiter Djinni
Find Zephyr, the third Jupiter Djinni
Find Smog, the fourth Jupiter Djinni
Find Kite, the fifth Jupiter Djinni
Find Squall, the sixth Jupiter Djinni
Find Luff, the seventh Jupiter Djinni
Find Fizz, the first Mercury Djinni
Find Sleet, the second Mercury Djinni
Find Mist, the third Mercury Djinni
Find Spritz, the fourth Mercury Djinni
Find Hail, the fifth Mercury Djinni
Find Tonic, the sixth Mercury Djinni
Find Dew, the seventh Mercury Djinni
Defeat the final boss and complete the game
Defeat 3 consecutive hordes of enemies in Battle Mode
Defeat 10 consecutive hordes of enemies in Battle Mode
Defeat 15 consecutive hordes of enemies in Battle Mode
Defeat 25 consecutive hordes of enemies in Battle Mode while Isaac is level 40 or higher
Defeat Tret
Complete the Mercury Lighthouse
Defeat the beast of Mogall Forest
Save Altin from the floods
Defeat the Manticore
Slay the Kraken
Win the Colosso Finals
Defeat the Storm Lizard
Outrun the Storm Lizard's tornado and escape Suhalla Desert
Defeat the Tempest Lizard
Get rewarded for saving a girl from being washed downstream
Rescue Hsu
Find out what happened to the Bandit Trio
Check in on Dora
Pick an imbalanced rowing team and explore the uncharted island
Rescue Lord Hammet
Defeat Deadbeard and obtain his treasure
Obtain the Kikuichimonji
Obtain the Blessed Mace
Obtain the Gaia Blade
Obtain the Muramasa and the Cleric's Ring
Obtain the Assassin Blade.
Complete the Mercury Lighthouse before fighting Tret
Clear the way to the ruins in Altin Peak before picking up the Orb of Force in Fuchin Falls