Survive the incident
Find the heart of the Sol Sanctum
Find the first Venus Djinni
Find the second Venus Djinni
Find the third Venus Djinni
Find the fourth Venus Djinni
Find the fifth Venus Djinni
Find the sixth Venus Djinni
Find the seventh Venus Djinni
Recruit Ivan
Find the first Mars Djinni
Find the second Mars Djinni
Find the third Mars Djinni
Find the fourth Mars Djinni
Find the fifth Mars Djinni
Find the sixth Mars Djinni
Find the seventh Mars Djinni
Find the first Jupiter Djinni
Find the second Jupiter Djinni
Find the third Jupiter Djinni
Find the fourth Jupiter Djinni
Find the fifth Jupiter Djinni
Find the sixth Jupiter Djinni
Find the seventh Jupiter Djinni
Find the first Mercury Djinni
Find the second Mercury Djinni
Find the third Mercury Djinni
Find the fourth Mercury Djinni
Find the fifth Mercury Djinni
Find the sixth Mercury Djinni
Find the seventh Mercury Djinni
Defeat the final boss and complete the game
Defeat 3 consecutive hordes of enemies in Battle Mode.
Defeat 10 consecutive hordes of enemies in Battle Mode.
Defeat 15 consecutive hordes of enemies in Battle Mode.
Defeat 25 consecutive hordes of enemies in Battle Mode while Isaac is level 40 or higher.
Defeat Tret
Complete the Mercury Lighthouse
Defeat the beast of Mogall Forest
Save Altin from the floods
Defeat the Manticore
Slay the Kraken
Win the Colosso Finals
Defeat the Storm Lizard
Outrun the Storm Lizard's tornado and escape Suhalla Desert
Defeat the Tempest Lizard
Get rewarded for saving a girl from being washed downstream
Rescue Hsu
Find out what happened to the Bandit Trio
Check in on Dora
Pick an imbalanced rowing team and explore the uncharted island
Rescue Lord Hammet
Defeat Deadbeard and obtain his treasure
Obtain the Kikuichimonji
Obtain the Blessed Mace
Obtain the Gaia Blade
Obtain the Muramasa and the Cleric's Ring
Obtain the Assassin Blade.
Complete the Mercury Lighthouse before fighting Tret
Clear the way to the ruins in Altin Peak before picking up the Orb of Force in Fuchin Falls