Defeat Your Rival in Oak's Lab

Obtain the Town Map from Your Rival's Sister

Defeat the Optional Rival Fight on Route 22

Defeat the Required Rival Fight on Route 22

Catch one of the three Starters

Defeat Brock and Earn the Boulder Badge

Defeat Brock on Set Mode, 2 Pokemon or Less [Levels=<17]

Defeat Brock's Rematch Team, Set Mode Active

Bought the Magikarp in the Pokemon Center just outside of Mt. Moon

Pick a Fossil at Mt. Moon

Defeat Misty and earn the Cascade Badge

Defeat Misty on Set Mode, 2 Pokemon or Less [Levels=<31]

Defeat Misty's Rematch Team, Set Mode Active

Defeat Your Rival in Cerulean City

Obtain the pass for the SS Anne

Defeat Your Rival on SS Anne

Defeat Lt. Surge and earn the Thunder Badge

Defeat Lt Surge on Set Mode, 3 Pokemon or Less [Levels=<42]

Defeat Lt. Surge's Rematch Team, Set Mode Active

Picked up the Eevee in Celadon City Mansion

Defeat Erika and earn the Rainbow Badge

Defeat Erika on Set Mode, 3 Pokemon or Less [Levels=<53]

Defeat Erika's Rematch Team, Set Mode Active

Defeat Giovanni at the Team Rocket Hideout in Celadon City

Defeat Your Rival at Lavender Tower

Rescue Mr Fuji and Obtain the Poke Flute

Defeat Koga and Earn the Soul Badge

Defeat Koga on Set Mode, 4 Pokemon or Less [Levels=<63]

Defeat Koga's Rematch Team, Set Mode Active

Defeat Your Rival at Silph Co.

Obtain the Gift Lapras at Silph Co.

Defeat Giovanni at Silph Co.

Defeat Sabrina and Earn the Marsh Badge

Defeat Sabrina on Set Mode, 4 Pokemon or Less [Levels=<72]

Defeat Sabrina's Rematch Team, Set Mode Active

Defeat Blaine and Earn the Volcano Badge

Defeat Blaine on Set Mode, 4 Pokemon or Less [Levels=<84]

Defeat Blaine's Rematch Team, Set Mode Active

Defeat Giovanni and Earn the Earth Badge

Defeat Giovanni on Set Mode, 5 Pokemon or Less [Levels=<91]

Defeat Giovanni's Rematch Team, Set Mode Active

Defeat Your Rival at the Elite Four

Defeat the Elite Four and Champion while on Set Mode, in one session [Set Mode On Before E4]

Find and Capture Mew, the Mythical Pokemon

Catch or Obtain all 151 Pokemon

Find and Defeat Dream Red

Discover and Defeat the True Final Boss of the Elite Four