Your first Game Over. Probably not the last one...
Unlock the Survive mode.
Reach a score over 1 000 000 !
That's a good start.
Reach the first prestige level.
Reach prestige 2.
Reach prestige 3.
Reach prestige 4.
Reach prestige 5.
Reach prestige 6.
Complete a run in Standard or Marathon with all modifiers at the same time.
Complete a run in Standard or Marathon with the Hard modifier.
Complete a run in Standard or Marathon with the Random Rooms modifier.
Complete a run in Standard or Marathon with the Friendly Fire modifier.
Complete a run in Standard or Marathon with the Overheat modifier.
Complete a Marathon run.
Complete a Survive run.
Watch the credits.
Complete a run without taking Overdrive damage.
Defeat a boss.