Take out the first 3 zombies you encounter without running away (NOTE: All achievements must be earned on Normal or higher except where noted. Infinite Ammo Unlocks will also disable achievements)

Officially team up with Billy to try and escape the train, after listening to some creepy opera guy

Kill the Stinger

Kill the Stinger without taking damage and using a Special Weapon

Collect the Hookshot

Watch Wesker and Birkin get confused as the leeches slaughter their team members

As Rebecca, put down the zombified Edward Dewey

As Rebecca, get past the zombified Edward and enter the Dining Car without taking damage, attacking him, or retreating into the previous car

Survive the speeding train crash

Activate the train brakes with at least 2:15 remaining on the timer without using the Rocket Launcher or Magnum Revolver

Kill all of the Crows in the Living Room ambush without running away

Kill the Centurion

Kill the Centurion in less than 30 seconds without using a Special Weapon

Unlock the Clock Doors in the Training Facility

Unlock the Sword Doors in the Training Facility

Complete the Statue Puzzle and lower Marcus' portrait to reveal a hidden path

Save Rebecca from falling, then learn about Billy's tragic backstory

As Billy, save Rebecca from falling within 10 seconds without using the Rocket Launcher or Magnum Revolver

Kill the Hunters in the Training Room without taking damage and without using a Special Weapon

Collect the Battery and reopen the room with Billy's surprise musical talent

Open all Fire and Water Key doors

Place all 3 tablets in the Observatory Tower to open the way forward

Kill the Giant Bat

Kill the Giant Bat without letting it grab you and without using a Special Weapon

Open the door with the Blue Leech Charm

Suddenly lose Billy as he gets jumped by one of those annoying monkeys

Restart the cable car and board it without getting hit by the Mimicry Marcus or its leeches, or trying to leave the Machine Room and without using a Special Weapon

See your S.T.A.R.S. Captain alive for the last time, which Rebecca helpfully reminds you about

Take down the Proto-Tyrant while waiting for the elevator in the Turntable Yard

Defeat the Proto-Tyrant in the Turntable Yard without taking damage and without using a Special Weapon

Reunite with Billy in the Treatment Plant

Kill the Proto-Tyrant in the Water Treatment Room

Kill the Proto-Tyrant in the Water Treatment Room without taking damage and without using a Special Weapon

After grabbing the Empty Battery, kill the Plague Crawlers that ambush you without running away

Defeat the first form of the Queen Leech

Defeat the Queen Leech's first form without letting it grab you or your partner and without using a Special Weapon

Kill the Queen Leech, say goodbye to your comrade, and head off to meet Alpha Team at the Mansion

Kill the Queen Leech with at least 3 minutes remaining on the timer and without using a Special Weapon

Complete the game with an S rank without having the Rocket Launcher unlocked

Complete the game within 2 hours and 30 minutes without having the Rocket Launcher unlocked

Complete the game with an S rank on Hard difficulty without having the Rocket Launcher unlocked

Complete the game within 2 hours and 30 minutes on Hard difficulty without having the Rocket Launcher unlocked

Complete the game without saving and without having the Rocket Launcher unlocked

Complete the game without saving on Hard difficulty and without any Special Weapon unlocks

Complete the game in one session using no weapons other than the Knife (Easy difficulty allowed)

Collect the Hunting Gun in the main game

Collect the Shotgun in the main game

Collect the Grenade Launcher in the main game

Collect the Magnum in the main game

Use the Handgun Parts to create a Custom Handgun in the main game

Mix together Empty Bottles and Gas Tanks to create Molotov Cocktails

Collect all of the Green, Red, and Blue Herbs in the game on Normal difficulty

Collect all of the First Aid Sprays in the game on Normal difficulty

Collect all of the Handgun Bullets in the game excluding the ammo from Edward's body on Normal difficulty

Collect all of the Shotgun Shells in the game on Normal difficulty

Collect all of the Grenade, Napalm, and Acid Rounds in the game on Normal difficulty

Collect all of the Magnum Bullets in the game on Normal difficulty

Collect all of the Submachine Gun Bullets in the game on Normal difficulty

Collect all of the Ink Ribbons in the game on Normal difficulty

Collect all of the Files and Maps in the game

Obtain at least 10 Leech Charms and finish Leech Hunter with an E Rank (does NOT stack with other ranks)

Obtain at least 30 Leech Charms and finish Leech Hunter with a D Rank (does NOT stack with other ranks)

Obtain at least 60 Leech Charms and finish Leech Hunter with a C Rank (does NOT stack with other ranks)

Obtain at least 90 Leech Charms and finish Leech Hunter with a B Rank (does NOT stack with other ranks)

Obtain 100 Leech Charms and finish Leech Hunter with an A Rank

Obtain at least 10 Leech Charms and finish Leech Hunter with an E Rank on Hard difficulty (does NOT stack with other ranks)

Obtain at least 30 Leech Charms and finish Leech Hunter with a D Rank on Hard difficulty (does NOT stack with other ranks)

Obtain at least 60 Leech Charms and finish Leech Hunter with a C Rank on Hard difficulty (does NOT stack with other ranks)

Obtain at least 90 Leech Charms and finish Leech Hunter with a B Rank on Hard difficulty (does NOT stack with other ranks)

Obtain 100 Leech Charms and finish Leech Hunter with an A Rank on Hard difficulty

Obtain an A Rank in Leech Hunter having maintained a Single Capture Average of 20 seconds or less

Collect the Submachine Gun in Leech Hunter

Collect the Magnum in Leech Hunter

Collect the Shotgun in Leech Hunter

Collect the Magnum Revolver in the main game after unlocking it in Leech Hunter

Change both Rebecca and Billy's Costumes using the Closet Key in the main game