Rescue Alessa from the fire in less than 80 seconds

Enter the Otherworld for the first time in the Alchemilla Hospital

Solve the Medical Icebox puzzle

Solve the Plastic Anatomy Doll puzzle

Defeat the first Straightjacket using only your fists, without equipping any weapons or taking damage, in the Alchemilla Hospital

Meet Lisa Garland for the first time

Observe an unsettling figure

Find the Target Pistol

Encounter a familiar woman in Cedar Grove Sanitarium

Solve the Iron Lung puzzle

Obtain the Shotgun

Find a Katana in Cedar Grove Sanitarium

Solve the Pill Cabinet puzzle

Defeat Momma using only your fists, without equipping any weapons or taking damage, in the Cedar Grove Sanitarium

Make your way out of the Cedar Grove Sanitarium

Ran into Lisa again at the theater, things aren't as they seem

Find the Service Pistol

Have both the Sun and Moon Totems in your inventory, then use them together to unlock the eastern corridor door

Find the Hunting Rifle

Solve the Spotlights puzzle

Activate and discover all three backstage sceneries in the Artaud Theater, without returning to the main menu

Defeat Caliban using only your fists, without equipping any weapons or taking damage, in Artaud Theater

Make your way out of the Artaud Theater

Find the Assault Rifle

Unlock the Cash Register in Andy's Bookstore

Make it inside the Riverside Motel

Witnessed a horrifying presence through a peephole in Riverside Motel

Find the Redeemer

Defeat The Butcher using only your fists and without equipping any weapons, in the Riverside Motel

Solve the Washing Machine puzzle

Solve the Rotary Calendar puzzle

Defeat Sad Daddy without taking damage or using any unlockable weapons in the Riverside Motel

Make it out of the Riverside Motel

Solve the Flauros puzzle

Defeat Alessa's Dream using only your fists and without equipping any weapons in the Otherworld

Reach the Good Ending

Reach the Bad Ending in NG+

Obtain the key to Room 502 in NG+

Reach the UFO Ending in NG+

Collect all 50 notes

Collect 300 items

While in Alchemilla Hospital, switch off your radio then kill all enemies without using unlockable weapons or returning to the main menu

Make it out of the Alchemilla Hospital without picking up the map and without returning to the main menu

While in Cedar Grove Sanitarium, switch off your radio then kill 10 enemies without using unlockable weapons or returning to the main menu

While in Artaud Theater, switch off your radio then kill 15 enemies without using unlockable weapons or returning to the main menu

While in Riverside Motel, switch off your radio then kill 15 enemies without using unlockable weapons or returning to the main menu

Make it through Nowhere to the Antique Shop without picking up the Child's Map

Perform 8 different execution animations on downed enemies without returning to the main menu

Finish off 50 enemies with a stomp attack

Kill 75 enemies with melee weapons

Kill 75 enemies with firearms

Kill 15 enemies using the Moon Gauntlets without returning to the main menu

Kill 15 enemies using the Fire Axe without returning to the main menu

Kill 15 enemies using the Great Cleaver without returning to the main menu

Kill 25 enemies using the Tesla Rifle without returning to the main menu

Do the Konami Code on NG+

Finish the game after rescuing Alessa from the fire in under 80 seconds

Finish the game with over 300 items collected

Finish the game looking at your map less than 25 times

Finish the game with a total distance traveled over 22.5 km

Finish the game while using your flashlight for less than 3 hours

Finish the game with at least 50% of enemies defeated using fists

Finish the game with at least 75% of enemies defeated using melee weapons

Finish the game with at least 75% of enemies defeated using firearms

Finish the game in less than 2 hours

Finish the game without saving