Complete the prologue without hurting the cop
Find a shortcut in the Warehouse on Nightmare difficulty
Defeat the Forklift Operator without taking damage
Defeat Doc Ock
Defeat Doc Ock without taking damage
Defeat The Lizard
Defeat The Lizard without taking damage
Defeat Electro
Defeat Electro without taking damage
Defeat the violent monkey roaming Central Park without taking damage
Defeat The Sandman
Defeat The Sandman without taking damage
Defeat the Brutal Biker without taking damage
Defeat The Hobgoblin
Defeat The Hobgoblin without taking damage
Defeat Venom and obtain the final key
Defeat Venom in any encounter without taking damage
Defeat Venom every time he appears on Nightmare difficulty
Defuse the bomb
Defuse the bomb with at least 21 hours remaining on the timer
Defeat The Kingpin without letting the chain descend at all
Defeat The Kingpin and rescue Mary Jane
Take two photographs at once
Take every unique photo in The Warehouse
Take every unique photo in The Sewers
Take every unique photo in The Power Station
Take every unique photo in Central Park
Take every unique photo in The City
Take a unique photo in The Caverns
Photograph Venom on every level on Nightmare difficulty
Complete the game on Nightmare difficulty, Tired Stamina and 3 Web Cartridges