Defeat a boss

Defeat a boss with an empty inventory

Defeat Diablo without taking damage

Defeat Diablo in 120 seconds

Defeat Diablo with no more than 18 unique items in inventory

Win a run as any character

Win a run as half of all characters

Win a run with the highest-difficulty character

Win a run as every character

Unlock all achievements

Win a round dealing at least 4000 damage with any item or implant

Pick up at least 10 potions in a round

Win a round with 0 gold

Win a round with at least 999 gold

Take at least 200 damage in a round

Buy "Ant Queen"

Fill all implant slots

Buy a legendary item

Summon at least 8 drones in a round

Collect at least 36 unique items in inventory

Win a run with at least 15 armor

Win a run with at least 80 health

Win a run with at least 30 curse

Win a run with negative move speed

Win a run with at least 10 reaction and 10 reaction limit

Deal at least 100 damage to a boss in a single hit while playing as Hunter

While playing as T-800, pierce 5 enemies with a single projectile

Win a run as 404 with at least 100 damage(stat)

Win a run as Null-Bot with positive reaction

Gain at least 60 gold from a single character ability activation while playing as Junkbot

Have at least 50 health during a round while playing as Sarcophagus

Win a run as V-Graf with positive recovery

While playing as Jester, make a projectile ricochet 5 times

Reduce curse by at least 25 with a single character ability activation while playing as Plague Legionary

Defeat Diablo with a critical hit while playing as Doomguy