Win the card battle in Night Patrol.
Win the card battle in High Tech Heist.
Complete all missions in Microchip Mayhem.
Complete all missions in Spidey to the Rescue.
Complete all missions in Weird Science.
Win the card battle in Enter the Octopus.
Win the two card battles against Goblin and complete the Chapter 1 - Spare Parts.
Win the card battle in Deadly Danger Room.
Win the card battle in Deathstrike.
Complete all missions in Muir Island.
Win the card battle in Lethal Gambit.
Complete all missions in Mutant Menace.
Win the card battle in Tooth and Nail.
Win the two card battles against Magneto and complete the Chapter 2 - Old Enemies, New Threats.
Complete all missions in Unpleasant Distraction.
Win the card battle in Negative Attitude.
Win the card battle in The Not-So-Fantastic Four.
Complete all missions in Crackin' Some Skrulls.
Complete all missions in Latverian Hospitality.
Complete all missions in Army of DOOM.
Win the three card battles against Dr. Doom and complete the Chapter 3 - Impending Doom.
Win the card battle in Hunted Heroes.
Win the card battle in Unfinished Business.
Win the card battle in Undead Interlude.
Complete all missions in Crime and Punishment.
Win the card battle in Maximum Carnage.
Complete all missions in Heroes United.
Win the card battle against Venom and complete the Chapter 4 - Vendetta.
Complete all missions in Heroes for Hire.
Complete all missions in Breaking and Entering.
Win the card battle in A Not-So-Clean Getaway.
Complete all missions in X-Static Rescue.
Complete all missions in Into the Underworld.
Complete all missions in Howling Mad.
Win the card battle in Strange Nightmare.
Win the card battle in Hand to Hand Combat.
Win the card battle against Bullseye and complete the Chapter 5 - Knight Moves.
Complete all missions in Enter the Kangs.
Complete all missions in Big Trouble.
Complete all missions in Mistaken Identity.
Complete all missions in The trask at Hand.
Complete all missions in Reinforcements.
Win the card battle in Hammer Time.
Complete all missions in Menace Out of Time.
Complete all missions in Supreme Effort.
Complete all missions in Kang Redux.
Complete all missions in More Kang for the Buck.
Complete all missions in Kang and Kang Again.
Win the card battle in Ultimate Evil.
Win the card battle against Kang and complete the Chapter 6 - Sinister Vengeance.
Win the card battle in Sinister Sentinels.
Win the card battle in Unlikely Allies.
Complete all missions in Common Enemy.
Win the card battle against Mr. Sinister in Final Showdown?.
Win the card battle against Master Mold, complete the Chapter 7 - Operation: Annihilate! and finish the hero campaign.
Win the card battle in Reprisals.
Win the card battle in Chips.
Complete all missions in Cloak and Dagger.
Complete all missions in Inside Job.
Complete all missions in The Goblin and the Octopus.
Win the card battle in Who's the Boss?.
Win the two card battles against Spider-Man and complete the Chapter 1 - Spare Parts.
Complete all missions in Breakout!.
Complete all missions in Roadblock.
Win the card battle in Barroom Blitz.
Win the card battle in Trading Faces.
Complete all missions in Springing the Trap.
Win the card battle in De-Clawed.
Win the two card battles against Professor Xavier and complete the Chapter 2 - Old Enemies, New Threats.
Win the card battle in The Siege of Atlantis.
Complete all missions in The Natives are Restless.
Win the card battle in Nasty Surprise.
Complete all missions in Invasion!.
Win the card battle in Namor.
Complete all missions in Uninvited Guests.
Win the two card battles against Human Torch and complete the Chapter 3 - Impending Doom.
Win the card battle in Open Season.
Win the card battle in Hunted.
Win the card battle in Kraven Punishment.
Complete all missions in Random Carnage.
Win the card battle in Clash of the Spiders.
Complete all missions in A Bridge Too Far.
Win the card battle against Spider-Man and complete the Chapter 4 - Vendetta.
Win the card battle in Late Night Visitor.
Complete all missions in Cage Match.
Complete all missions in X-Static Ambush.
Win the card battle in One Hell of a Fight.
Complete all missions in Bad Voodoo.
Complete all missions in Children of the Night.
Win the card battle in Diversionary Tactics.
Complete all missions in Hand it Over.
Win the card battle against Elektra and complete the Chapter 5 - Knight Moves.
Complete all missions in Dark Disguise.
Complete all missions in Trask.
Complete all missions in Thunderbolts No More!.
Complete all missions in Masters of Evil.
Complete all missions in Thunderstorm.
Win the two card battles against Captain America in Kang Rising.
Complete all missions in Wrecked.
Complete all missions in Dark Pharaoh.
Complete all missions in The Growing Menace.
Win the card battle in Supreme Sacrifice.
Finish all missions in God of Thunder and complete the Chapter 6 - Sinister Vengeance.
Win the card battle against Master Mold, complete the Chapter 7 - Operation: Annihilate! and finish the villain campaign.
Buy your first playmat.
Buy all playmats.
Complete all the Basic Puzzles.
Complete all the Loyalty Puzzles.
Complete all the Boost Puzzles.
Complete all the Evasion Puzzles.
Complete all the Reservist Puzzles.
Complete all the Concealed Puzzles.
Complete all the Leader Puzzles.
Complete all the Puzzles.
Get 180% of the game.