Unlock all trophies.
Clear Act One on any difficulty.
Clear Act Two on any difficulty.
Clear Act Three on any difficulty.
Clear Act Four on any difficulty.
Clear Act Five on any difficulty.
Clear Act Six on any difficulty.
Clear Act Seven on any difficulty.
Clear Act Eight on any difficulty.
Clear Act Nine on any difficulty.
Clear Vengeance on Assisted Difficulty or higher.
Clear Vengeance on Easy Difficulty or higher.
Clear Vengeance on Normal Difficulty or higher.
Clear Vengeance on Biohazard Difficulty or higher.
Clear Vengeance on Nightmare Difficulty or higher.
Clear Vengeance on Apocalyptic Difficulty or higher.
Reach Wave 30 in Magnum Opus on Normal Difficulty or higher.
Reach Wave 30 in Magnum Opus on Biohazard Difficulty or higher.
Reach Wave 30 in Magnum Opus on Nightmare Difficulty or higher.
Clear Vengeance with at least one gameplay modifier active.
Clear Vengeance with at least two gameplay modifiers active.
Clear Vengeance with at least three gameplay modifiers active.
Clear Vengeance with at least four gameplay modifiers active.
Clear Vengeance with at least five gameplay modifiers active.
Clear Vengeance with at least six gameplay modifiers active.
Reach Wave 30 in Magnum Opus with at least two gameplay modifiers active.
Reach Wave 30 in Magnum Opus with at least three gameplay modifiers active.
Reach Wave 30 in Magnum Opus with at least four gameplay modifiers active.
Reach Wave 30 in Magnum Opus with at least five gameplay modifiers active.
Reach Wave 30 in Magnum Opus with at least six gameplay modifiers active.
Play Magnum Opus.