Acquire all trophies.
Upgrade any poison to Rank 2.
Unlock a skill by upgrading a poison.
Upgrade one poison to Rank 5.
Upgrade 10 total Toxicants, Antidotes, or Catalysts to Rank 5.
Acquire a poison by collecting three poison gems for the first time.
Acquire every Deliriant at least once.
Acquire every Toxicant, Antidote, and Catalyst.
Reach Level 10.
Reach Level 30.
Reach Level 50.
Defeat 100 Kleshas
Defeat 500 Kleshas
Defeat 1,000 Kleshas
Unlock a skill during a Heart-to-Heart.
Unlock a Toxicant slot by reaching Insight Level 3.
Max out your Synergy Level.
Max out your Empathy Level.
Max out your Insight Level.
Max out your Toxicity Level.
Max out your Trust Level.
Purify your first Belle's Hell.
Reach the Second Circle of Hell.
Reach the Third Circle of Hell.
Reach the Fourth Circle of Hell.
Reach the Fifth Circle of Hell.
Clear all Belles' Hells.
Defeat Black Poisonette
Defeat White Poisonette
Complete the game with any Normal Ending.
Complete the game with the Yomi Sake Bottle Ending.
Speak to your first thoughtform.
Have your first Heart-to-Heart.
Purchase the Yomi Sake Bottle.