Defeat your rival in Professor Oak's Lab.

Win the optional battle against your rival on Route 22.

Defeat your rival in Cerulean City.

Defeat your rival on the S.S. Anne.

Defeat your rival in Lavender Town.

Defeat your rival in Saffron City.

Defeat your rival on your way to the Pokémon League.

Stop Team Rocket in Celadon City.

Stop Team Rocket in Saffron City.

Defeat Brock in Pewter City and earn the Boulder Badge.

Defeat Misty in Cerulean City and earn the Cascade Badge.

Defeat Lt. Surge in Vermillion City and earn the Thunder Badge.

Defeat Erika in Celadon City and earn the Rainbow Badge.

Defeat Koga in Fuchsia City and earn the Soul Badge.

Defeat Sabrina in Saffron City and earn the Marsh Badge.

Defeat Blaine on Cinnabar Island and earn the Volcano Badge.

Defeat Giovanni in Viridian City and earn the Earth Badge.

Become the League Champion.

Return stronger and become the League Champion again.

Catch a Chansey.

Catch Moltres.

Catch Zapdos.

Catch Articuno.

Catch Mewtwo.

Catch Raikou, Entei, or Suicune.

Catch all 171 obtainable Pokémon without external trades.

Rescue Lostelle on Island 3.

Help Lorelei in stopping Team Rocket on Island 4.

Rescue Selphy on Island 5.

Stop Team Rocket in their warehouse on Island 5.

Complete the Single Battle challenge at the Trainer Tower.

Complete the Double Battle challenge at the Trainer Tower.

Complete the Knockout Battle challenge at the Trainer Tower.

Complete the Mixed Battle challenge at the Trainer Tower.

Obtain the Pokédex from Professor Oak

Obtain the Town Map from Daisy

Obtain a free Potion from the Poké Mart worker on Route 1

Obtain the Teachy TV after being taught how to catch Pokémon

Unlock the use of Mystery Gift

Defeat the trainer in Pewter City Gym

Buy the Magikarp in the Route 4 Pokémon Center

Pick either the Dome or Helix Fossil in Mt. Moon

Defeat every trainer in Cerulean City Gym

Obtain the S.S. Anne Pass from Bill

Obtain the Old Rod in Vermillion City

Obtain the Bike Voucher in Vermillion City

Trade a Spearow for a Farfetch'd in Vermillion City

Trade an Abra for a Mr. Mime on Route 2

Obtain the Bicycle in Cerulean City

Defeat every trainer and find every overworld item in Viridian Forest

Defeat every trainer and find every item on the S.S. Anne before it leaves

Defeat every trainer in Vermilion City Gym

Obtain HM05 Flash from one of Professor Oak's Aides

Obtain the Old Amber in the Pewter City Museum

Defeat every trainer and find every item in Rock Tunnel

Obtain the Everstone from Professor Oak's Aide on Route 10

Obtain the gift Eevee in Celadon City

Obtain the Coin Case in Celadon City

Obtain all of the hidden and gift coins in the Celadon City Game Corner

Defeat every trainer in Celadon City Gym

Obtain HM02 on Route 16

Gain access to Saffron City by giving the Guards tea

Obtain the VS Seeker in Vermilion City

Obtain the Powder Jar in Cerulean City

Defeat every trainer and find every item in the Rocket Hideout

Defeat every trainer and find every item in the Pokémon Tower

Obtain the Poké Flute in Lavender Town

Catch a Wild Snorlax

Obtain both HM03 Surf and HM04 Strength

Obtain the Itemfinder from Professor Oak's Aide on Route 11

Find both hidden Leftovers that can only be found using the Itemfinder

Obtain the hidden Soothe Bell in Pokémon Tower

Defeat every trainer and find every item in Mt. Moon (Except hidden Mushrooms)

Defeat every trainer and find every item on Routes 2, 3, and 4, and Viridian, Pewter, and Cerulean City

Defeat every trainer and find every item on Routes 24 and 25

Obtain the Good Rod in Fuchsia City

Obtain the Amulet Coin from Professor Oak's Aide on Route 16

Obtain the Super Rod on Route 12

Obtain the Exp Share from Professor Oak's Aide on Route 15

Defeat every trainer in Fuchsia City Gym

Find every item in the Safari Zone

Defeat every trainer and find every item on Routes 9 and 10

Find every item in the Power Plant

Defeat every trainer and find every item on Routes 6, 7, 8, Saffron City, and Vermilion City

Defeat every trainer and find every item on Routes 11, 12, 13, 14, 15, and Fuchsia City

Defeat every trainer and find every item on Routes 19, 20, and 21

Find every item in Seafoam Island

Defeat every trainer and find every item in Pokemon Mansion

Defeat every trainer and find every item in Silph Co.

Defeat every trainer in the Saffron City Dojo and obtain either Hitmonlee or Hitmonchan

Defeat every trainer in the Saffron City Gym

Obtain the Secret Key

Defeat every trainer in the Cinnabar Island Gym

Defeat every trainer in the Viridian City Gym

Obtain the Gift Lapras in Silph Co.

Defeat every trainer and find every item on Routes 16, 17, 18 and Celadon City

Obtain the Macho Brace in Viridian City Gym

Show the Fishing Guru on Route 12 a Magikarp big enough to earn a reward

Defeat every trainer and find every item on Route 23 and Victory Road

Complete all 3 trades on Cinnabar Island

Complete both trades for a Male Nidoran and a Nidorino

Trade a Poliwhirl for a Jynx in Cerulean City

Trade a Slowbro for a Lickitung on Route 18

Defeat every trainer and find every item in Treasure Beach, Kindle Road and Mt. Ember

Obtain HM06 Rock Smash at the Ember Spa

Find the PP Max at Cape Brink by using the Itemfinder

Defeat every trainer and find every item on Two Island, Cape Brink, Three Island, Bond Bridge, and Berry Forest

Deplete the Berry Forest of all its renewable berries

Obtain the National Pokédex

Obtain a Nugget from the Miner in Three Isle Path

Obtain the Ruby in Mt. Ember

Find every item on Four Island and Icefall Cave

Obtain HM07 Waterfall in Icefall Cave

Defeat every trainer and find every item in the Five Island region

Defeat every trainer and find every item in the Six Island region

Defeat every trainer and find every item in the Seven Island region

Obtain an egg in the Water Labyrinth

Show a record-breaking Heracross to a woman in Water Path for the first time and earn a Nest Ball

Show Selphy the Pokémon that she asked for and obtain a reward

Bring the Ruby and Sapphire back to Celio and have him finally finish the machine

Obtain every Fame Checker entry, fully filling it out

Use the machine in the Game Corner to add at least one Pokémon to the back of your Trainer Card

Find every item in Cerulean Cave

Find and use all of the Move Tutors

Hit triple 7s on the slots in the Celadon City Game Corner

Obtain all three TMs from the thirsty girl on the rooftop of the Celadon Department Store

Find the Sapphire in the Dotted Hole and then have your efforts go down in vain

Defeat the highest leveled teams for all rematchable trainers found in the Vs. Seeker