Earn all trophies.
Complete the train.
Complete the training facility.
Complete the laboratory.
Complete the factory.
Complete the treatment plant.
Finish the game with rank S.
Finish the game on Hard difficulty.
Finish the game without combining herbs.
Finish the game without saving.
Finish the game without using a First-Aid Spray.
Finish the game without using a recovery item (including Green Chemicals).
Defeat Infected Bat.
Fight off the Proto Tyrant.
Defeat the Proto Tyrant.
Defeat Queen Leech.
Defeat all bosses except Centurion using Rebecca.
Defeat an enemy with a critical-hit headshot.
Defeat an enemy by burning them.
Defeat a zombie by stomping on them.
Create a Molotov Cocktail.
Change into a costume.
Attack an enemy to save your partner who is grappling with that enemy.
Defeat an enemy with a knife.
Destroy a zombie's legs.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Break free of a Cerberus while they are biting you or trying to push you down.
Create a Custom Handgun.
Use a Green Chemical.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Read all files.
Obtain all keys and use them all.
Defeat Mimicry Marcus for the first time only using a knife.
Combine every type of herb with each other.
Obtain all weapons.
Defeat 16 bats in the church.
Put on Team Wesker costume.
Play the piano using Rebecca.
Try to push something heavy with Rebecca.
Get picked up by the Infected Bat.
Play Leech Hunter.
Finish Leech Hunter with rank A.
Finish Leech Hunter with rank E or above.
Collect all of only one color of Leech Charms.
Defeat all enemies in Leech Hunter.
Kill 50 enemies with the Death Stare at full charge.