Beat the game using only the knife in one session [Hard Mode, Unequip any weapon at the beginning of the game and never equip it again, unequip it as soon as you get control of Carlos]
Defeat the 1st Nemesis using only the knife without taking damage [Hard Mode, Equip the knife before the battle start, save after nemesis appear is not allowed]
Defeat the 2nd Nemesis using only the knife without taking damage [Hard Mode, Equip the knife before the battle start, save after nemesis appear is not allowed]
Defeat the 3rd Nemesis using only the knife without taking damage [Hard Mode, Equip the knife before the battle start, save after nemesis appear is not allowed, Carlos Banned]
Defeat the 4th Nemesis using only the knife without taking damage [Hard Mode, Equip the knife before the battle start, save after nemesis appear is not allowed, Carlos Banned]
Defeat the 5th Nemesis using only the knife without taking damage [Hard Mode, Equip the knife before the battle start, save after nemesis appear is not allowed]
Defeat the 6th Nemesis using only the knife without taking damage [Hard Mode, Equip the knife before the battle start, save after nemesis appear is not allowed]
Defeat the 7th Nemesis using only the knife without taking damage [Hard Mode, Equip the knife before the battle start, save after nemesis appear is not allowed]