Return to the station 5 times

Jump a total of 500 times

Discover a secret room for the first time

Offer at least 3 hearts, per area, at a statue

Offer HP to at least 20 small shrines

Refuse to pick up a pickup and leave the room instead

Collect 200 pickups

Hold at least 10 Keys in a run at once (without having Skeleton Key)

Use Keys to open 30 Gates

Collect 10 HP pickups in a single run

Gain at least 4 max HP during a run purely by overhealing

Visit the Chef at least 15 times across all runs

Make it through an entire boss fight with 0.5 HP

Collect 500 Souls in a single run

Open 3 small chests in a run

Find a smaller chest inside a small chest

Win a Relic at the chest lottery at least 3 times

Mimics can now spawn across the Tower

Fully upgrade 4 Relics at the blacksmith during one run

Recycle 4 Relics via the twins in a single run and win

Have 12 max HP in a run at once

Have 12 shields in a run at once

Destroy 15 Relics overall

Get a Synergy

Collect 3 legendary Relics in a single run

Have at least 3 familiar Relics at the same time

Have at least 3 orbital Relics at the same time

Achieve at least +50% luck in a single run

Die due to getting hit by your own explosives

Beat a room without touching the ground after the first hit

Defeat 3 minibosses during a single run

Listen to the Dummy questioning your motives

Pet the cat a total of 10 times

Beat a run and don't disturb any small critters

Use a reroll machine 3 times in a single shop

Get nothing from the same vending machine twice in a row

Get 3 pickups from the same vending machine in a row

Fill up a health machine fully

Steal from a shop

Empty out a claw machine without failing once

Clear out 5 shops during a single run

Buy something from the metro merchant before entering the second area

Visit a Black Market

Collect a total amount of 100 Soul Coins

Collect a total amount of 1000 Soul Coins

Collect a total amount of 10000 Soul Coins

Collect 15 Curses across all runs

Hold at least 5 Curses in a run at once

Remove 5 Curses

Accept a corrupted room deal 10 times

Open a cursed chest in each area of a run and win

Beat a run in which you obtain at least 5 Curses, while always picking the rightmost Curse

Beat a full run while having the custom shard modifier, cursed relics, set to the maximum

Beat a full run, while having at least 8 corrupted hearts

Corrupted rifts can now spawn across the Tower

Enter 2 Corrupted Rifts in a single run

Beat a corrupted guardian

Collect 25 Tickets

Use 50 Tickets

Use 200 Tickets

Purchase 30 Tickets from the Ticket machine

Collect 3 Celestial Weapons in a single run

Catch 20 different types of fish

Catch 40 different types of fish

Catch all different types of fish

Obtain every single fishing lure

Unleash the Loop Lord

Beat a looped run

Beat a full run on at least Loop 3

Beat a full run on at least Loop 5

Unlock your first Soul Gun

Unlock all Soul Gun types

Unlock every single Soul Gun variant

Beat a full Shard 10 run at least once with every Soul Gun variant

Obtain your first golden Soul Gun

Obtain the golden version of every single Soul Gun variation

Beat a full Chaos Ticket run on Shard 15 or higher

Beat a run and do not focus in at least 2 different areas

Unlock all portal shortcuts at the Technician

Enter a golden rift

Unlock at least 3 Soul Torches

Meet with the king of all frogs

Beat a run in under 20 minutes

Defeat a boss without shooting once

Beat a run without picking up any Relics along the way

Beat a run without taking a single hit

Visit every normal and alt area in a single run

Collect 50% of all hats

Collect all hats

Unlock all Relics at the Imprisoned

Unlock all expansions at the Tinkerer

Unlock all music pieces from the Fool

Free all lost souls

Gain at least a silver medal in every section of the Journal

Fully complete the Journal

Beat the Gazing Grove

Beat the Gazing Grove without taking a single hit

Defeat Denial, by shooting them while they have their eye open

Beat the Fungated Funnels

Beat the Fungated Funnels without taking a single hit

Defeat Anger without defeating any other enemies during the fight

Bee hives now appear across the Gazing Grove

Beat the Hollow Hives

Beat the Hollow Hives without taking a single hit

Uncover the Forgotten Station

Beat the Arid Athenaeum

Beat the Arid Athenaeum without taking a single hit

Defeat Bargaining while they are spinning on the ground

Beat the Somber Sepulcher

Beat the Somber Sepulcher without taking a single hit

Defeat Depression without dashing and without getting hit twice

Snow statues now appear across the Arid Athenaeum

Beat the Calm Caldarium

Beat the Calm Caldarium without taking a single hit

Beat the Ticking Towertop

Beat the Ticking Towertop without taking a single hit

The bedroom door is now permanently opened on Shard 5 and above

Uncover the Last Refuge

Beat the Last Refuge

Beat the Last Refuge without taking a single hit

Uncover the Void

Beat a run on Shard 5

Beat a full run on Shard 10

Beat a full run on Shard 20

Beat a full run on Shard 30

Unlock all other secrets

Take 15 Curses from cursed statues