Rescue the hostages and safely dispose of the bomb
Resolve the hostage situation and stop the bomb without taking damage
Defeat 14 enemies while 'racing' to the Bugle
Defeat Scorpion and rescue Jameson! Because... Reasons
Defeat Scorpion without Spidey or Jameson taking damage and without letting Scorpion find Jameson
Reach the top of the building on the Missile Attack level without stopping or taking damage
Locate the Green Goblin's lair
Complete all five levels of the police chase without attacking any cops
Destroy all four transformers and defeat Rhino without taking damage
Defeat Venom for the first time
Defeat Venom for the first time without throwing a single punch or kick or being grabbed by Venom
Knock 25 lizardmen off the subway car
Find the Lizard in the maze
Reach the end of the Lizard's maze in less than 50 seconds
Defeat Venom again and rescue your wife... again
Defeat Venom without taking damage or allowing the water flow to be turned back on
Locate the spidey armor in the elevator shaft
Find three magnesium cartridges in the Bugle's Basement
Defeat Mysterio and find out what this has all been about
Defeat Mysterio while missing no more than three shots with your impact webs
Collect the hidden Spidey armor in the waterfront warehouse ventilation shaft
Cross the Underwater Trench without taking damage (Normal or higher difficulty)
Defeat Doc Ock
Defeat Doc Ock without taking damage before his shield can regenerate for a second time
Defeat Carnage without letting him get off a single attack
Escape from Monster Ock and save the world! ... Again
What if one of the Fantasic Four was around?
What if Peter Parker could bust a move?
What if Spider-Man didn't save Jameson?
What if Spider-Man hitched a ride on a blimp?
What if Spider-Man annoyed the Lizard?
What if Spider-Man activated all four switches and drowned his wife?
What if Spider-Man found his impostor?
What if Spider-Man raided the lost ark?
What if Spider-Man won a race against a yellow submarine? (Normal or higher difficulty)
What if Black Cat got footloose?
What if Doc Ock was only 6 inches tall?
What If Venom's prime suspect was guilty?
Take out 15 Lizardmen in Time Attack Training
Survive for 3:00 against the symbiotes in suvival training
Complete Speed Training 1 in less than 0:40
Complete Speed Training 2 in less than 1:30
Complete Speed Training 3 in less than 0:45
Score 18 points in Target Practice
Complete Item Hunt training in less than 1:10
Earn 10,000 points in Zip-Line training
Rescue all the hostages in the Daily Bugle and defeat Mysterio as Spider-Man 2099
Make your way through the sewers, defeat Venom and rescue Mary Jane as Symbiote Spider-Man
Defeat the three final bosses as Captain Universe
Rescue the hostages in the bank and defuse the bomb as Spidey Unlimited
Defeat Rhino as Scarlet Spidey
Infiltrate the Waterfront Warehouse and rescue Black Cat as the Amazing Bag Man!
Catch Venom and kick the crap out of him as Ben Reilly
Escape the Cops as Quick-Change Spidey
Race to the Bugle and rescue Jameson as Peter Parker
Collect all comics
Unlock All Costumes
Complete the game on Hard difficulty