Reach Miskatonic University.

Perform the ritual.

Discharge yourself from Akeley Memorial.

Survive the Arkham Fish Market.

Awaken.

Obtain the shotgun.

Obtain the submachine gun.

Obtain the rifle.

Obtain the grenade launcher.

Defeat three nightmares in the hospital.

Investigate the wall safe.

Investigate the church mystery.

Investigate the cursed press.

Investigate the alluring song.

Investigate the machine connected to the brains.

Investigate the locked storage.

Investigate the mysterious locker.

Investigate the sixteen punishments.

Listen to every Mushroom Jack broadcast in one playthrough.

Read all the writings that weren't there before.

Unlock every Emergency Relief Crate in one playthrough (excluding DLC).

Obtain all Talents.

Unlock all achievements.