Beat Challenge Mode as Tom.

Beat Challenge Mode as Jerry.

Beat Challenge Mode as Spike.

Beat Challenge Mode as Butch.

Beat Challenge Mode as Nibbles.

Beat Challenge Mode as Duckling.

Beat Challenge Mode as Tyke.

Beat Challenge Mode as Eagle.

Beat Challenge Mode as Lion.

Unlock all the costumes for Tom.

Unlock all the costumes for Jerry.

Unlock all the costumes for Spike.

Unlock all the costumes for Butch.

Unlock all the costumes for Nibbles.

Unlock all the costumes for Duckling.

Defeat Monster Jerry in Challenge Mode on Hard before he devolves. (Can be played in Versus Mode under the same conditions for quick, unlimited retries. [Hard - Player's Power: 3 - CPU's Power: 6 - Victory under 20 seconds])

Defeat Robot Cat in Challenge Mode on Hard staying far enough away to avoid him from making his rotary attack. (Can be played in Versus Mode under the same conditions for quick, unlimited retries. [Hard - Player's Power: 3 - CPU's Power: 6])

Beat Challenge Mode with every character.

In Challenge or Versus Mode, poison an opponent until knock out in "A Fridge Too Far" with its special weapon.

In Challenge or Versus Mode, defeat an opponent in "Haunted Mouse" through a 3-hit combo with its special weapon.

In Challenge or Versus Mode, defeat an opponent in "Scrap Yard Scrape Up" with its special weapon.

In Challenge or Versus Mode, defeat an opponent in "That Sinking Feline" with its special weapon.

In Challenge or Versus Mode, freeze an opponent until knock out in "Snow Fight" with its special weapon.

In Challenge or Versus Mode, defeat an opponent in "Luncheons and Dragons" through a 3-hit combo with its special weapon.

In Challenge or Versus Mode, defeat an opponent in "Paws" with its special weapon.

In Challenge or Versus Mode, defeat an opponent in "Towering Infurno" by hitting them perfectly with its special weapon.

In Challenge or Versus Mode, call the bees in "Ciao Meow" with its special weapon and let them defeat your opponent for you.

In Tag Versus Mode, win a round as Tom & Butch against Jerry & Nibbles in "A Fridge Too Far" while leaving the map intact. [Hard - Unlimited Time - All characters set to Max Power]

In Versus Mode, win a round as Lion against Monster Jerry in "Haunted Mouse" without repeating any of your attacks. [Hard - Unlimited Time - All characters set to Max Power]

In Challenge or Versus Mode, get your opponent inside the "Crusha" four times in "Scrap Yard Scrape Up" during a single round on Hard.

In Versus Mode, win a round as Jerry against Duckling in "Snow Fight" only by throwing items. [Hard - Unlimited Time - All characters set to Max Power]

In Versus Mode, win a round as Tom against Nibbles in "Luncheons and Dragons" attacking only with melee weapons. [Hard - Unlimited Time - All characters set to Max Power]

In Versus Mode, win a round as Butch against Tom in "Paws" without your Berserk Bar ever reaching 100%. [Hard - Unlimited Time - Butch set to Min Power - Tom set to Max Power]

In Challenge or Versus Mode, defeat an opponent in "Unfurgiven" with its special weapon.

In Challenge or Versus Mode, defeat an opponent in "Frankenmouse" with its special weapon or any of the stage's hazards.

In Versus Mode, win a round as Tom against Jerry in "That Sinking Feline" grabbing and attacking only with the items the CPU throws at you. [Hard - Unlimited Time - All characters set to Max Power]

In Challenge or Versus Mode, manage to get your opponent stuck in the cement in "Towering Infurno" on Hard.

In Tag Versus Mode, win a round without letting the CPU switch characters in "Unfurgiven".

In Tag Versus Mode, win a round as Eagle & Butch against Nibbles & Duckling in "Ciao Meow" only attacking while in Berserk Mode. [Hard - Unlimited Time - All characters set to Max Power]

In Tag Versus Mode, win a round as Tom & Robot Cat against Jerry & Monster Jerry in "Frankenmouse" without using the same character for more than 10 seconds in a row. [Hard - Unlimited Time - All characters set to Max Power]

Beat Challenge Mode as Tom in 3:30 or less. [Hard - Unlimited Time]

Beat Challenge Mode as Jerry in 3:55 or less. [Hard - Unlimited Time]

Beat Challenge Mode as Spike in 3:15 or less. [Hard - Unlimited Time]

Beat Challenge Mode as Butch in 3:25 or less. [Hard - Unlimited Time]

Beat Challenge Mode as Nibbles in 4:30 or less. [Hard - Unlimited Time]

Beat Challenge Mode as Duckling in 4:10 or less. [Hard - Unlimited Time]

Beat Challenge Mode as Tyke in 4:15 or less. [Hard - Unlimited Time]

Beat Challenge Mode as Eagle in 2:35 or less. [Hard - Unlimited Time]

Beat Challenge Mode as Lion in 3:40 or less. [Hard - Unlimited Time]

In Challenge or Versus Mode, win a round with a Purrfect Score.

In Challenge or Versus Mode, win a round with a Purrfect Score without healing. [Hard - CPU set to Max Power and being any character but Robot Cat]

In Challenge Mode, throw the Kjeldahl Flask at Monster Jerry to devolve him within the first 5 seconds of the match.

Unlock four costumes during the same round.

In Tag Versus Mode, defeat Jerry & Monster Jerry in "Haunted Mouse" in 2:00 or less using only Robot Cat. [Hard - Unlimited Time - All characters set to Max Power]

In Tag Versus Mode, defeat Tom & Butch in "Frankenmouse" in 0:30 or less using only Monster Jerry. [Hard - Unlimited Time - All characters set to Max Power]