You need to die. Just once. It'll be painless.
Unlock the Breakneck Divine Burden.
Unlock the Deadline Divine Burden.
Unlock the Deadly Divine Burden.
Unlock the Eclipse Divine Burden.
Unlock the Excessive Divine Burden.
Unlock the Rebirth Divine Burden.
Unlock the Stout Divine Burden.
Unlock the Unhelpful Divine Burden.
Unlock the portal to the Gardens.
Unlock the portal to the Catacombs.
Unlock the portal to the Palace.
Reach the final Boss Fight.
Complete the game for the first time.
Complete the game without using any wish portals.
Complete the game with all Divine Burdens turned on. No Portals. No Blessings.